The method in brief
Through this webpage, you will compute few standard neutrality tests that are solely based on the frequency spectrum:For now, sites with indel are completely ignored and when more than 2 symbols exist at a site, the second most frequent is used to compute the frequency. All the other ones are pooled and considered as the most frequent one.
More tests can be implemented if requested.
- D (Tajima, 1989)
- D2*, F*, D2, F (Fu and Li, 1993)
- H (Fay and Wu, 2000)
- Y and Y* (Achaz, 2008)
- Ω tests --Generic tests (Achaz, 2009)--
Online version of the neutrality tests
This program has been written in C. It is originally part of a library (libdiversity) of functions that does manage aligned sequences and compute many standard population genetics metrics (The library is available upon request). The source of this stand-alone web-adapted version can be viewed at neutralitytst.c (compiled as 'gcc -o neutralitytest.cgi -O2 -DMACOSX neutralitytest.c -lm'). I would be happy to incorporate any interesting suggestions.
If you have any suggestions/comments, please send them to Guillaume Achaz: firstname.lastname@example.org